During his lifetime, he held several political posts, especially in Nigeria. They include Executive Committee Member of Mambili Party, Accra (1935–37); General Secretary of National Council of Nigerian and the Cameroons (1944–45); President of the NCNC (1946–60); Vice-President of the Nigerian National Democratic Party (1947–60); Member for Lagos in the Legislative Council of Nigeria (1947–51); Member for Lagos and Leader of the Opposition in the Western House of Assembly (1952–53) Member for Onitsha in the Eastern House of Assembly (1954–60); Minister of Internal Affairs (Jan.–September 1954); Minister of Internal Affairs, Eastern Region (1954); Member of His Excellency Privy Council, Eastern Nigeria (1954–59); Primer of Eastern Nigeria (1954–59); President of the Senate of the Federation (January–November 1960); Governor-General and Commander-in-Chief of Nigeria (1960–63); President of the Republic of Nigeria (1963–1966); and Chairman and Presidential candidate of the Nigeria People's Party (1978–83).
